MAIT cells specific for microbial metabolites
نویسندگان
چکیده
منابع مشابه
The role of certain microbial metabolites as specific complexing agents.
The discovery of microbial metabolites—macrotetrolides, siderochromes and boromycin—is reviewed. The structures of these and related compounds provide instructuve examples of how Nature has solved the problem of cornplexing certain rarer elements, such as potassium, iron and boron. The common structural features of these highly specific, natural complexing agents are briefly discussed. It was e...
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Techniques of immobilization of microbial- cells have been established by multifunctional reagents such as glutaraldehyed on a solid support. Immobilized cell reactor was designed to demonstrate stability of cross linking of whole cells for the production of organic acids. An eighty-six percent conversion of glucose was obtained for an eight hour retention time. The immobilized cell reacto...
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Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the detection of microbial compounds presented by the evolutionarily conserved major-histocompatibility-complex (MHC) class I molecule, MR1. Here we show that MAIT cells display cytotoxic activity towards MR1 overexpressing non-hematopoietic cells ...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2012
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri3334